Proximal Convoluted Tubules as the Primary Target of Renal Histopathological Injury by Ingestion of Pesticide-Residue-Laden Fruits and Vegetables

Objective: To determine the potential adverse renal histopathological effects on the proximal convoluted tubules in male, Wistar rats due to ingestion of subchronic dose of triazophos. Study Design: Randomized controlled trial. Place and Duration of Study: A study of 3 weeks duration (plus 1 week for slide preparation & histological study), was held in the animal house-PGMI, Bird wood road, Lahore. Materials and Methods: Two equal groups were made, of 6 Wistar, male rats each. Group A was control while experimental group B was given triazophos, in a dose of 8.2 mg/kg-subchronic dose (1/10 of LD 50), a commonly used pesticide, as 1:100 dilution solution through oral gavage for 21 consecutive days. On day 22, the rats were sacrificed and tissues preserved for histological examination and measurement of proximal and distal tubular diameters by using micrometric grid. Results: The micrometric measurement of diameters of PCT in group A and B indicated that they increased significantly from 38.90 ± 2.72μm in group A to 50.35 ± 2.61μm in group B (p-value