Preclinical Experimental Study on New Cervical Implant Design to Improve Peri-Implant Tissue Healing

In this preclinical study, we used an experimental rabbit model to investigate the effects of a new implant design that involves specific changes to the cervical portion, using a conventional implant design in the control group. We used 10 rabbits and 40 dental implants with two different macrogeome...

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Veröffentlicht in:Bioengineering (Basel) 2024-11, Vol.11 (11), p.1155
Hauptverfasser: Gehrke, Sergio Alexandre, Cortellari, Guillermo Castro, Júnior, Jaime Aramburú, Treichel, Tiago Luis Eilers, Bianchini, Marco Aurelio, Scarano, Antonio, De Aza, Piedad N
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Sprache:eng
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Zusammenfassung:In this preclinical study, we used an experimental rabbit model to investigate the effects of a new implant design that involves specific changes to the cervical portion, using a conventional implant design in the control group. We used 10 rabbits and 40 dental implants with two different macrogeometries. Two groups were formed (n = 20 per group): the Collo group, wherein implants with the new cervical design were used, which present a concavity (reduction in diameter) in the first 3.5 mm, the portion without surface treatment; the Control group, wherein conical implants with the conventional design were used, with surface treatment throughout the body. All implants were 4 mm in diameter and 10 mm in length. The initial implant stability quotient (ISQ) was measured immediately after the implant insertion (T1) and sample removal (T2 and T3). The animals (n = five animals/time) were euthanized at 3 weeks (T1) and 4 weeks (T2). Histological sections were prepared and the bone-implant contact (BIC%) and tissue area fraction occupancy (TAFO%) percentages were analyzed in the predetermined cervical area; namely, the first 4 mm from the implant platform. The ISQ values showed no statistical differences at T1 and T2 ( = 0.9458 and = 0.1103, respectively) between the groups. However, at T3, higher values were found for the Collo group ( = 0.0475) than those found for the Control group. The Collo samples presented higher BIC% values than those of the Control group, with statistical differences of = 0.0009 at 3 weeks and = 0.0007 at 4 weeks. There were statistical differences in the TAFO% (new bone, medullary spaces, and the collagen matrix) between the groups at each evaluation time ( < 0.001). Considering the limitations of the present preclinical study, the results demonstrate that the new implant design (the Collo group) had higher implant stability (ISQ) values in the samples after 4 weeks of implantation. Furthermore, the histomorphometric BIC% and TAFO% analyses showed that the Collo group had higher values at both measurement times than the Control group did. These findings indicate that changes made to the cervical design of the Collo group implants may benefit the maintenance of peri-implant tissue health.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11111155