Association between 5-HTTLPR and STin2 VNTR polymorphisms in the serotonin transporter gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in lifelong premature ejaculation

The effects of 5-hydroxytryptamine (serotonin) transporter gene-linked polymorphic region (5-HTTLPR) and serotonin transporter gene intron 2 (STin2) polymorphism on lifelong PE (LPE) are controversial. According to the Clinician Global Impression of Change score, 66.3% (63/95) of the patients treated with dapoxetine showed efficacy. The chi-square test for the frequencies of the 5-HTTLPR LS genotype, LS + SS genotype, and the LL genotype showed the P value and the odds ratio (OR) value (95% confidence interval [CI]) were P = 0.735, OR (95% CI) = 0.869 (0.272, 2.655), P = 0.258, OR (95% CI) = 0.330 (0.260, 1.522), indicating that the difference was not statistically significant (P > 0.05). In our present research, the comparison of SS and LL genotype distribution frequency of 5-HTTLPR was statistically significantly different between the two groups.