Orexin - does it have a role in mental illness?

Orexin - does it have a role in mental illness?

Orexin-A and Orexin-B (also known as hypocretin 1 and 2) are, respectively, 33- and 28-amino acid residue peptides that activate a G-protein-coupled 'orphan' receptor, i.e. which has no known ligand. Immuno-cytochemical studies show that orexin-positive neurons are located in the lateral h...

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Veröffentlicht in:The South African journal of psychiatry 2008-06, Vol.14 (2), p.63-64
Hauptverfasser: Jeenah, F.Y, Moosa, M.Y.H
Format: Artikel
Sprache:eng
Schlagworte:
Adverse and side effects
Drugs
Health aspects
Hypothalamic hormones
Mental illness
Risk factors
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Zusammenfassung:Orexin-A and Orexin-B (also known as hypocretin 1 and 2) are, respectively, 33- and 28-amino acid residue peptides that activate a G-protein-coupled 'orphan' receptor, i.e. which has no known ligand. Immuno-cytochemical studies show that orexin-positive neurons are located in the lateral hypothalamic area and arcuate and perifornical nuclei.
ISSN:1608-9685
2078-6786
DOI:10.4102/sajpsychiatry.v14i2.159