Association of maternal obesity with preterm birth phenotype and mediation effects of gestational diabetes mellitus and preeclampsia: a prospective cohort study

The association between maternal obesity and preterm birth remains controversial and inconclusive, and the effects of gestational diabetes mellitus (GDM) and preeclampsia (PE) on the relationship between obesity and preterm birth have not been studied. We aimed to clarify the relationship between pr...

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Veröffentlicht in:	BMC Pregnancy and Childbirth 2022-06, Vol.22 (1), p.459-459, Article 459
Hauptverfasser:	Liu, Kan, Chen, Yixuan, Tong, Jianing, Yin, Aiqi, Wu, Linlin, Niu, Jianmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Body mass index Cohort analysis Complications and side effects Diabetes in pregnancy Expected values Gestational age Gestational diabetes Gestational diabetes mellitus Gynecology Hypertension Menstruation Obesity Overweight Phenotype Preeclampsia Pregnancy Premature birth Prepregnancy BMI Preterm birth Prevention Public health Reproductive technologies Risk factors Ultrasonic imaging Variables Womens health
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Beschreibung
Zusammenfassung:	The association between maternal obesity and preterm birth remains controversial and inconclusive, and the effects of gestational diabetes mellitus (GDM) and preeclampsia (PE) on the relationship between obesity and preterm birth have not been studied. We aimed to clarify the relationship between prepregnancy body mass index (BMI) and the phenotypes of preterm birth and evaluate the mediation effects of GDM and PE on the relationship between prepregnancy BMI and preterm birth. We conducted a prospective cohort study of 43,056 women with live singleton births from 2017 through 2019. According to the WHO International Classification, BMI was classified as underweight (BMI
ISSN:	1471-2393 1471-2393
DOI:	10.1186/s12884-022-04780-2