Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia

Background Circadian rhythm disorders, often seen in modern lifestyles, are a major social health concern. The aim of this study was to examine whether circadian rhythm disorders would influence angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia. Methods and Results A j...

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Veröffentlicht in:	Journal of the American Heart Association 2021-08, Vol.10 (16), p.e020896-e020896
Hauptverfasser:	Tsuzuki, Kazuhito, Shimizu, Yuuki, Suzuki, Junya, Pu, Zhongyue, Yamaguchi, Shukuro, Fujikawa, Yusuke, Kato, Katsuhiro, Ohashi, Koji, Takefuji, Mikito, Bando, Yasuko K, Ouchi, Noriyuki, Calvert, John W, Shibata, Rei, Murohara, Toyoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Movement Cell Proliferation Cells, Cultured Circadian Rhythm cryptochrome Cryptochromes - genetics Cryptochromes - metabolism Disease Models, Animal endothelial progenitor cell Endothelial Progenitor Cells - metabolism Gene Expression Regulation hind limb ischemia Hindlimb - blood supply Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Humans Ischemia - blood Ischemia - complications Ischemia - genetics Ischemia - physiopathology Jet Lag Syndrome - blood Jet Lag Syndrome - complications Jet Lag Syndrome - genetics Jet Lag Syndrome - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Microvascular Density Neovascularization, Physiologic Original Research Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Regional Blood Flow Signal Transduction Time Factors vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood
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Zusammenfassung:	Background Circadian rhythm disorders, often seen in modern lifestyles, are a major social health concern. The aim of this study was to examine whether circadian rhythm disorders would influence angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia. Methods and Results A jet-lag model was established in C57BL/6J mice using a light-controlled isolation box. Control mice were kept at a light/dark 12:12 (12-hour light and 12-hour dark) condition. Concentrations of plasma vascular endothelial growth factor and circulating endothelial progenitor cells in control mice formed a circadian rhythm, which was diminished in the jet-lag model (
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.121.020896