Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure

New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients under...

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Veröffentlicht in:	Scientific reports 2024-03, Vol.14 (1), p.5811-5811, Article 5811
Hauptverfasser:	Frisk, Christoffer, Das, Sarbashis, Eriksson, Maria J., Walentinsson, Anna, Corbascio, Matthias, Hage, Camilla, Kumar, Chanchal, Ekström, Mattias, Maret, Eva, Persson, Hans, Linde, Cecilia, Persson, Bengt
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/1647/2017 692/4019 Actin Apoptosis Biopsy Cardiac biopsy Cardiac muscle Congestive heart failure Cytoskeleton Echocardiography Gene expression Gene Expression Profiling Heart failure Heart Failure - diagnosis Heart Failure - genetics Heart Ventricles Humanities and Social Sciences Humans Ion channels (cyclic nucleotide-gated) Ischemic heart disease Left ventricular dysfunction multidisciplinary Muscle contraction Peptides Phenotypes Principal components analysis Science Science (multidisciplinary) Smooth muscle Stat4 protein Stroke Volume - physiology Transcription factors Transcriptomics Ventricle Ventricular Dysfunction, Left Ventricular Function, Left β-Catenin
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Zusammenfassung:	New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients undergoing elective coronary bypass surgery (CABG). Patients were categorised based on LV ejection fraction (EF), diastolic function and NT-proBNP into pEF (preserved; LVEF ≥ 45%), rEF (reduced; LVEF
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-56025-1