Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various σR ligands generate cancer cell death in vitro and in vivo. These σR ligands have exhibited promising result...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-08, Vol.22 (9), p.1408
Hauptverfasser:	Georgiadis, Markos-Orestis, Karoutzou, Olga, Foscolos, Angeliki-Sofia, Papanastasiou, Ioannis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antiproliferative activity Antiproliferatives Antitumor activity biomarkers Cancer Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Clinical trials Drugs Fluorescent Dyes - chemistry Humans Ligands Molecular Probes Molecular Targeted Therapy Neoplasms - diagnosis Neoplasms - drug therapy radiolabeled and fluorescent probes Radiopharmaceuticals - chemistry Receptors, sigma - agonists Receptors, sigma - antagonists & inhibitors Review Rodentia sigma 1 receptor antagonist sigma 2 receptor agonist
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Beschreibung
Zusammenfassung:	Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various σR ligands generate cancer cell death in vitro and in vivo. These σR ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules22091408