SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020–January 2021

•By December 2020, 24.1% of the general population in India had been exposed to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).•For every case of coronavirus disease 2019 detected, there were 27 infections.•Seroprevalence was higher in urban areas compared with rural areas.•By December...

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Veröffentlicht in:International journal of infectious diseases 2021-07, Vol.108, p.145-155
Hauptverfasser: Murhekar, Manoj V., Bhatnagar, Tarun, Thangaraj, Jeromie Wesley Vivian, Kumar, Muthusamy Santhosh, Selvaraju, Sriram, Rade, Kiran, Kumar, C.P. Girish, Sabarinathan, R., Turuk, Alka, Asthana, Smita, Bangar, Sampada Dipak, Bansal, Avi Kumar, Chopra, Vishal, Devi, Kangjam Rekha, Dhikav, Vikas, Dwivedi, Gaurav Raj, Khan, S. Muhammad Salim, Kumar, M. Sunil, Laxmaiah, Avula, Madhukar, Major, Mahapatra, Amarendra, Rangaraju, Chethana, Yadav, Rajiv, Andhalkar, Rushikesh, Arunraj, K., Bharadwaj, Dinesh Kumar, Bharti, Pravin, Bhattacharya, Debdutta, Chahal, Ashrafjit S., Chaudhury, Anshuman, Dayal, Rakesh, Elantamilan, D., Haq, Inaamul, Hudda, Ramesh Kumar, Jagjeevan, Babu, Kalliath, Arshad, Kanungo, Srikanta, Krishnan, Nivethitha N., Kumar, Alok, Lakshmi, G.G.J. Naga, Mehta, Ganesh, Mishra, Nandan Kumar, Mitra, Anindya, Nagbhushanam, K., Nimmathota, Arlappa, Nirmala, A.R., Prasad, Ganta Venkata, Qurieshi, Mariya Amin, Reddy, Sirasanambatti Devarajulu, Robinson, Aby, Sahay, Seema, Saxena, Rochak, Sekar, Krithikaa, Singh, Hari Bhan, Singh, Pushpendra, Viramgami, Ankit, Wilson, Vimith Cheruvathoor, Chakrabarti, Amit, Das, Aparup, Dhaliwal, R.S., Kant, Rajni, Narain, Kanwar, Narasimhaiah, Somashekar, Padmapriyadarshini, Chandrasekaran, Pati, Sanghamitra, Ramarao, Tekumalla, Sharma, Y.K., Singh, Shalini, Reddy, D.C.S., Bhargava, Balram, Anand, Tanu, Babu, Giridhara R., Chauhan, Himanshu, Dikid, Tanzin, Gangakhedkar, Raman R., Kant, Shashi, Kulkarni, Sanket, Pandey, Ravindra Mohan, Shah, Naman, Shrivastava, Aakash, Singh, Sujeet K., Zodpe, Sanjay, Hindupur, Anusha, Chellakumar, M., Chokkalingam, D., Gowtham, M.M.E., Jose, Annamma, Kalaiyarasi, K., Karthik, N.N., Karunakaran, T., Sarath Kumar, S., Sarath Kumar, M.P., Michaelraj, E., Pradhan, Josephine, Arun Prasath, E.B., Rani, Sudha, Rozario, Amanda, Gnana Soundari, P., Sujeetha, K., Vinod, Arya
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Zusammenfassung:•By December 2020, 24.1% of the general population in India had been exposed to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).•For every case of coronavirus disease 2019 detected, there were 27 infections.•Seroprevalence was higher in urban areas compared with rural areas.•By December 2020, 25.6% healthcare workers had evidence of SARS-CoV-2 infection. Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May–June 2020 and 7.1% in August–September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India. The third serosurvey was conducted in the same 70 districts as the first and second serosurveys. For each district, at least 400 individuals aged ≥10 years from the general population and 100 HCWs from subdistrict-level health facilities were enrolled. Serum samples from the general population were tested for the presence of immunoglobulin G (IgG) antibodies against the nucleocapsid (N) and spike (S1-RBD) proteins of SARS-CoV-2, whereas serum samples from HCWs were tested for anti-S1-RBD. Weighted seroprevalence adjusted for assay characteristics was estimated. Of the 28,598 serum samples from the general population, 4585 (16%) had IgG antibodies against the N protein, 6647 (23.2%) had IgG antibodies against the S1-RBD protein, and 7436 (26%) had IgG antibodies against either the N protein or the S1-RBD protein. Weighted and assay-characteristic-adjusted seroprevalence against either of the antibodies was 24.1% [95% confidence interval (CI) 23.0–25.3%]. Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI 23.5–27.8%). Nearly one in four individuals aged ≥10 years from the general population as well as HCWs in India had been exposed to SARS-CoV-2 by December 2020.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2021.05.040