Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis

Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sep...

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Veröffentlicht in:Frontiers in endocrinology (Lausanne) 2020-11, Vol.11, p.599255-599255
Hauptverfasser: Ruiz-Sánchez, Jorge Gabriel, Núñez-Gil, Ivan J, Cuesta, Martin, Rubio, Miguel A, Maroun-Eid, Charbel, Arroyo-Espliguero, Ramón, Romero, Rodolfo, Becerra-Muñoz, Victor Manuel, Uribarri, Aitor, Feltes, Gisela, Trabattoni, Daniela, Molina, María, García Aguado, Marcos, Pepe, Martino, Cerrato, Enrico, Alfonso, Emilio, Castro Mejía, Alex Fernando, Roubin, Sergio Raposeiras, Buzón, Luis, Bondia, Elvira, Marin, Francisco, López Pais, Javier, Abumayyaleh, Mohammad, D'Ascenzo, Fabrizio, Rondano, Elisa, Huang, Jia, Fernandez-Perez, Cristina, Macaya, Carlos, de Miguel Novoa, Paz, Calle-Pascual, Alfonso L, Estrada Perez, Vicente, Runkle, Isabelle
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Sprache:eng
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Zusammenfassung:Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive therapy (IT) in patients hospitalized with SARS-COV2 pneumonia. This is a retrospective study of the HOPE-COVID-19 registry, with data collected from January 1 through April 31 , 2020. We selected all hospitalized adult patients with RT-PCR-confirmed SARS-COV2 pneumonia and a registered admission serum sodium level (SNa). Patients were classified as hyponatremic (SNa 145 mmol/L). Multivariable analyses were performed to elucidate independent relationships of admission hyponatremia and hypernatremia, with mortality, sepsis, or IT during hospitalization. Four thousand six hundred sixty-four patients were analyzed, median age 66 (52-77), 58% males. Death occurred in 988 (21.2%) patients, sepsis was diagnosed in 551 (12%) and IT in 838 (18.4%). Hyponatremia was present in 957/4,664 (20.5%) patients, and hypernatremia in 174/4,664 (3.7%). Both hyponatremia and hypernatremia were associated with mortality and sepsis. Only hyponatremia was associated with IT. In conclusion, hyponatremia and hypernatremia at admission are factors independently associated with mortality and sepsis in patients hospitalized with SARS-COV2 pneumonia. https://clinicaltrials.gov/ct2/show/NCT04334291, NCT04334291.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.599255