Relative effectiveness and safety of pharmacotherapeutic agents for patent ductus arteriosus (PDA) in preterm infants: a protocol for a multicentre comparative effectiveness study (CANRxPDA)

IntroductionPatent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding the best treatment approach is lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exi...

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Veröffentlicht in:	BMJ open 2021-05, Vol.11 (5), p.e050682-e050682
Hauptverfasser:	Mitra, Souvik, Jain, Amish, Ting, Joseph Y., Ben Fadel, Nadya, Drolet, Christine, Abou Mehrem, Ayman, Soraisham, Amuchou, Jasani, Bonny, Louis, Deepak, Lapointe, Anie, Dorling, Jon, Khurshid, Faiza, Hyderi, Abbas, Kumaran, Kumar, Bodani, Jaya, Weisz, Dany, Alvaro, Ruben, Adie, Mohammed, Stavel, Miroslav, Morin, Alyssa, Bhattacharya, Soume, Kanungo, Jaideep, Canning, Rody, Ye, Xiang Y, Hatfield, Tara, Gardner, Courtney E, Shah, Prakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Birth weight Canada Clinical outcomes Clinical trials Congenital diseases Coronary vessels Drug dosages Drug therapy Ductus Arteriosus, Patent - drug therapy Effectiveness studies Enzymes Gestational age Humans Ibuprofen - therapeutic use Indomethacin - adverse effects Infant Infant, Low Birth Weight Infant, Newborn Multicenter Studies as Topic neonatal intensive & critical care neonatology Newborn babies Nonsteroidal anti-inflammatory drugs Observational Studies as Topic paediatric cardiology Paediatrics Pediatrics Premature babies
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Zusammenfassung:	IntroductionPatent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding the best treatment approach is lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exists in PDA treatment practices across Canada. In view of this large practice variation across Canadian neonatal intensive care units (NICUs), we plan to conduct a comparative effectiveness study of the different pharmacotherapeutic agents used to treat the PDA in preterm infants.Methods and analysisA multicentre prospective observational comparative-effectiveness research study of extremely preterm infants born
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2021-050682