A comparative analysis of influenza and COVID-19: Environmental-ecological impacts, socioeconomic implications, and future challenges

•We systematically reviewed the impacts of climate change, environmental, and socioeconomic factors on influenza and COVID-19 prevalence.•We analyzed and assessed the impacts of COVID-19 pandemic on the occurrence and epidemic of influenza.•We summarized lessons and implications to refine public health strategies, enhance pandemic preparedness, and strengthen healthcare system resilience. In the last century, global pandemics have been primarily driven by respiratory infections, which consistently rank among the top 20 causes of death worldwide. The coronavirus disease 2019 (COVID-19) pandemic has underscored the intricate nature of managing multiple health crises simultaneously. In recent years, climate change has emerged as a major biosafety and population health challenge. Global warming and extreme weather events have intensified outbreaks of climate-sensitive infectious diseases, especially respiratory diseases. Influenza and COVID-19 have emerged as two of the most significant respiratory pandemics, each with unique epidemic characteristics and far-reaching consequences. Our comparative analysis reveals that while both diseases exhibit high transmission rates, COVID-19′s longer incubation period and higher severity have led to more profound and prolonged socioeconomic disruptions than influenza. Both pandemics have highlighted the exacerbating effects of climate change, with extreme weather events intensifying the spread and impact of these diseases. The COVID-19 pandemic exposed vulnerabilities in global healthcare systems and economies on an unprecedented scale, outstripping the strain caused by influenza outbreaks. Importantly, the COVID-19 pandemic has not only reshaped global public health strategies but also significantly impacted the epidemiology of influenza. Despite these differences and associations, both diseases underscore the urgent need for robust pandemic preparedness and adaptable public health strategies. This review delineates the overlaps and distinctions between influenza and COVID-19, offering insights into future challenges and the critical steps needed to enhance healthcare system resilience and improve global responses to pandemics.