Clinicopathological and prognostic value of Ki-67 expression in oral malignant melanoma: A systematic review and meta-analysis

Ki-67 is one of the new biological markers with clinical value in the pathology and prognosis of oral melanoma. It is a nuclear protein involved in regulating cell proliferation. Some studies have suggested an association between Ki-67 and poor survival in patients with oral melanoma. This systemati...

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Veröffentlicht in:	Journal of dental research, dental clinics, dental prospects dental clinics, dental prospects, 2022-01, Vol.16 (3), p.140-146
Hauptverfasser:	Moltajaei, Mohammad Hossein, Pourzare Mehrbani, Solmaz, Motahari, Paria, Rezapour, Ramin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Biomarkers Cell cycle Cell division Cell growth Cell proliferation Content analysis Keywords ki-67 Laboratories Malignancy Medical prognosis Melanoma Meta-analysis Oral cancer oral malignant melanoma Patients Prognosis Review Skin cancer Software Systematic review Tumors
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Zusammenfassung:	Ki-67 is one of the new biological markers with clinical value in the pathology and prognosis of oral melanoma. It is a nuclear protein involved in regulating cell proliferation. Some studies have suggested an association between Ki-67 and poor survival in patients with oral melanoma. This systematic review was undertaken to clarify this issue. Databases of PubMed, Scopus, and Web of Science were searched using relevant English keywords from 1988 to April 2022. STATA software version 16 and random models were used for meta-analysis. Eleven articles were included in this systematic review, six of which were selected for meta-analysis. The mean expression of the Ki-67 index in patients with oral melanoma was estimated at 43.81% (28.66‒58.95 with 95% CI, I =94.2,
ISSN:	2008-210X 2008-2118
DOI:	10.34172/joddd.2022.024