Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma

Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma

Background and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Canadian journal of gastroenterology & hepatology 2018-01, Vol.2018 (2018), p.1-8
Hauptverfasser: Resende, Vivian, Junior, Eduardo Paulino, Vasconcellos, Leonardo de Souza, Rodrigues, João Bernardo Sancio Rocha, Machado, Carla Jorge, Lima, Leonardo do Prado, Vidigal, Paula Vieira Teixeira
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
alpha-Fetoproteins - metabolism
Antigens
Biomarkers, Tumor - blood
Blood Vessels - pathology
Cancer
Cancer therapies
Carcinoma
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cell adhesion & migration
Children
Epithelial Cell Adhesion Molecule - metabolism
Female
Gene expression
Glycoproteins
Hepatocellular carcinoma
Histopathology
Humans
Immunohistochemistry
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Lymphatic Vessels - pathology
Male
Middle Aged
Neoplasm Invasiveness
Novels
Patients
Phenotypes
Proteins
Statistical analysis
Stem cells
Surgery
Survival analysis
Survival Rate
Tumor Burden
Tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p
ISSN:2291-2789
2291-2797
DOI:10.1155/2018/5970852