OP-2 Bowman’s layer in health, keratoconus and other corneal conditions

PurposeTo investigate the central thickness of Bowman’s layer in patients with keratoconus, healthy cornea and other corneal conditions in relation to corneal curvature and, epithelial and total corneal thickness in health, keratoconus (KC) and Fuchs’ endothelial corneal dystrophy (FED).MethodsPatients with keratoconus, FED and other dystrophies, and healthy subjects were included. Linnik and Mirau ultra high axial resolution line field spectral domain optical coherence tomography (UHR-OCT) devices were used to image the cornea, in addition to commercially available OCT and Scheimpflug devices. Measurements were undertaken in triplicate for each device at entry and then repeated at 3 and 6 months. A supervised automated segmentation process was used to extract the quasi-point thickness of the Bowman’s layer in the central cornea from the collected UHR-OCT images.Results37 patients with KC, 33 with FED and other corneal dystrophies and 18 healthy subjects were included. Central BT 14.32uM (SD:1.66) in KC, 15.45 (SD 1.88) in health and 15.20 (1.42) in FED. Central Bowman’s layer thickness, was associated with CCT (p