Cytotoxicity and Antioxidant Potential of Novel 2-(2-((1H-indol-5yl)methylene)-hydrazinyl)-thiazole Derivatives

Newly synthesized 2-(2-((1 -indol-5yl)methylene)-hydrazinyl)-thiazole derivatives were evaluated for their in vitro cytotoxicity on two carcinoma cell lines A2780 and HeLa. Significant cytotoxic activity for 2-(2-((1 -indol-5-yl)methylene)hydrazinyl)-4-methylthiazole ( ) and 2-(2-((1 -indol-5-yl)methylene)hydrazinyl)-4-phenylthiazole ( ), on both A2780 [IC : 11.6 μM ( ), and 12.4 μM ( )] and HeLa [IC : 22.4 μM ( ) and 19.4μM ( )] cell lines is reported. Their antioxidant potential was evaluated by spectrophotometric method, using DPPH radical or Fe (TPTZ) complex, and EPR spectroscopy, therefore the compounds and showed remarkable antioxidant activity simultaneously with a cytotoxic effect on A2780 and HeLa cell lines. Furthermore, based on theoretical quantum chemical calculation, the present study analyzed the chemoselectivity of the hydrogen extraction from the indolyl-hydrazinil-thiazoles in reaction with free radicals.