Analysis of single nucleotide polymorphisms in chronic beryllium disease

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidos...

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Veröffentlicht in:	Respiratory research 2021-04, Vol.22 (1), p.107-5, Article 107
Hauptverfasser:	Frye, Björn C, Gaede, Karoline I, Saltini, Cesare, Rossman, Milton D, Monos, Dimitri S, Rosenman, Ken D, Schuler, Christine R, Weston, Ainsley, Wegner, Ralf, Noth, Rainer, Zissel, Gernot, Schreiber, Stefan, Nothnagel, Michael, Müller-Quernheim, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A11 Antigens Berylliosis Berylliosis chronic Beryllium Beryllium diesase Bone cancer BTNL2 Cytokines Disease Exposure Genes Genetic Letter to the Editor Nucleotides Polymorphism Sarcoidosis Single-nucleotide polymorphism Source studies Surveillance Trigger factor Values
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Zusammenfassung:	Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.
ISSN:	1465-993X 1465-9921 1465-993X 1465-9921
DOI:	10.1186/s12931-021-01691-2