Mean platelet volume in acute coronary syndrome: Diagnostic implications

Objective: The aim of the present study was to investigate the association between mean platelet volume (MPV) and platelet count in patients with diagnosis of acute coronary syndrome (ACS). Materials and Methods: It was a case–control study conducted in a tertiary care hospital. We examined 100 cases of ACS and 100 age- and sex-matched healthy controls. All patients were subjected to focused history, focused clinical examination, vital recording, and baseline 12 lead electrocardiogram. MPV and platelet count were measured by a hemogram device, Melet Schloesing (MS-9) based on the Coulter principle. Results: The patients with ACS had a higher MPV 7.70 fl as compared to the normal healthy controls 6.64 fl (P < 0.0001). On the other hand, the platelet count was significantly decreased in the patients of ACS 172.44 × 109/L when compared with the healthy control group 204.98 × 109/L, and this difference was statistically significant with P < 0.0001. Conclusions: We concluded that the patients presenting with features of ACS have a higher MPV and a decreased platelet count as compared to normal population. These simple hematological markers such as MPV and platelet count can help us in reaching the diagnosis of ACS along with traditional tools.