Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO

Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectr...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2013-04, Vol.18 (4), p.4181-4191
Hauptverfasser:	Yoshikawa, Kazuko, Koso, Kazuaki, Shimomura, Masumi, Tanaka, Masami, Yamamoto, Hirofumi, Imagawa, Hiroshi, Arihara, Shigenobu, Hashimoto, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	5-lipoxygenase (5-LO) Acids Carbon cryptoporic acid Crystallography, X-Ray Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology cyclooxygenase-1 (COX-1) and COX-2 DNA polymerase Fomitella fraxinea fomitellanol Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - pharmacology Magnetic Resonance Spectroscopy Polycyclic Sesquiterpenes Polyporaceae Polyporaceae - metabolism Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Spectrum analysis
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Zusammenfassung:	Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses, and their biological activity against COX-1, COX-2, and 5-LO was investigated.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules18044181