Plasma-derived exosomal miR-326, a prognostic biomarker and novel candidate for treatment of drug resistant pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a cancer with high incidence rate in pediatrics and drug resistance is a major clinical concern for ALL treatment. The current study was designed to evaluate the role of exosomal miR-326 in diagnosis and treatment of children with B-ALL. Exosomes were isolated f...

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Veröffentlicht in:	Scientific reports 2024-01, Vol.14 (1), p.691-691, Article 691
Hauptverfasser:	Saffari, Neda, Rahgozar, Soheila, Faraji, Elaheh, Sahin, Fikrettin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/67 631/80 692/308 692/4017 692/4028 692/53 Acute lymphoblastic leukemia Cancer Cell culture Cell viability Drug resistance Electron microscopy Exosomes Fluorescence microscopy Humanities and Social Sciences Immunoblotting Internalization Leukemia Lymphatic leukemia Microscopy multidisciplinary Nanoparticles Patients Pediatrics Science Science (multidisciplinary) Transfection
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Beschreibung
Zusammenfassung:	Acute lymphoblastic leukemia (ALL) is a cancer with high incidence rate in pediatrics and drug resistance is a major clinical concern for ALL treatment. The current study was designed to evaluate the role of exosomal miR-326 in diagnosis and treatment of children with B-ALL. Exosomes were isolated from plasma samples of 30 patients and B-ALL cell lines followed by characterization, using nanoparticle tracking analysis, immunoblotting assay and electron microscopy. qPCR showed significantly increased levels of miR-326 in patients exosomes compared with non-cancer controls ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-50628-w