IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

•Immunoglobulin light like polypeptides 5 gene (IGLL5) is expressed in mature-B-cell lymphoma lacking IGλ protein.•IGLL5 expression is controlled by super-enhancer, predicted by in-silico analyses.•Decreased expression of IGLL5 results in apoptosis with down-expression of MYC. IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words)