Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we dis...

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Veröffentlicht in:VACCINES 2021-01, Vol.9 (1), p.61
Hauptverfasser: Cagigi, Alberto, Loré, Karin
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive immunity
Animal models
antibody response
Antigens
Bioavailability
COVID-19
dendritic cell
Immune response
Immune system
Infections
Lipids
Lymphatic system
Monkeys
mRNA
mRNA vaccine
mRNA vaccines
Nanoparticles
Polyethylene glycol
protein translation
Proteins
Review
Severe acute respiratory syndrome coronavirus 2
Th1 polarization
type I interferon
Vaccines
Viral infections
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Beschreibung
Zusammenfassung:In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9010061