Hepatitis C: a critical analysis of therapeutic response predictors

Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, inc...

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Veröffentlicht in:	The Brazilian journal of infectious diseases 2002-04, Vol.6 (2), p.74-81
Hauptverfasser:	Focaccia, R, Siciliano, R F, Santos, E D B, Boccardo, E, Conceição, O J G, Barbosa, U O, Galante, V C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood ALT normalization Antiviral Agents - therapeutic use Drug Evaluation - methods Drug Evaluation - standards Hepacivirus - genetics Hepacivirus - isolation & purification hepatitis C Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Humans INFECTIOUS DISEASES Interferons - therapeutic use Liver - pathology Liver - virology Viral Load viral load reduction
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Zusammenfassung:	Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, including serum alanine aminotransferase (ALT) normalization, viral load reduction and improvement of hepatic histology.
ISSN:	1413-8670 1678-4391
DOI:	10.1590/S1413-86702002000200003