Dedifferentiation: the return road to repair the intestinal epithelium

In the March 5 issue of Cell Stem Cell , (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust r...

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Veröffentlicht in:	Cell Regeneration 2020-06, Vol.9 (1), p.2-2, Article 2
Hauptverfasser:	Liu, Yuan, Xiong, Xiaochen, Chen, Ye-Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Biomedical and Life Sciences Biomedicine Cell Biology Cell differentiation Epithelium Gene expression Growth Homeostasis Inflammatory bowel disease Intestine Life Sciences Observations Progenitor cells Regenerative medicine Research Highlight Stem Cells Tissue engineering Transcription factors
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Zusammenfassung:	In the March 5 issue of Cell Stem Cell , (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust regenerative capability of the intestinal epithelium via dedifferentiation of absorptive and secretory progenitors in the crypt.
ISSN:	2045-9769 2045-9769
DOI:	10.1186/s13619-020-00048-2