3-(4-Fluorophenyl)- em>N /em>-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N -arylation of pyrazolone ( 1 ) using copper(I) iodide catalyst followed by reduction to give amine ( 2 ). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound ( 3 ).