Methanolic Fractions of Ornithogalum cuspidatum Induce Apoptosis in PC-3 Prostate Cancer Cell Line and WEHI-164 Fibrosarcoma Cancer Cell Line

Methanolic Fractions of Ornithogalum cuspidatum Induce Apoptosis in PC-3 Prostate Cancer Cell Line and WEHI-164 Fibrosarcoma Cancer Cell Line

The present study, was aimed to assess the cytotoxic effects of Ornithogalum cuspidatum methanolic fractions on PC-3, prostate cancer cells and WEHI-164, Fibrosarcoma cells. Methanolic fractions of O. cuspidatum were prepared using solid phase extraction and the cells were treated with different con...

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Veröffentlicht in:Advanced pharmaceutical bulletin 2014-10, Vol.4 (Suppl 1), p.455-458
Hauptverfasser: Asadi, Hamed, Orangi, Mona, Shanehbandi, Dariush, Babaloo, Zohreh, Delazar, Abbas, Mohammadnejad, Leila, Zare Shahneh, Fatemeh, Valiyari, Samira, Baradaran, Behzad
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cancer
Methanolic Fraction
Ornithogalum cuspidatum
PC-3 cell line
WEHI-164 cell line
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Zusammenfassung:The present study, was aimed to assess the cytotoxic effects of Ornithogalum cuspidatum methanolic fractions on PC-3, prostate cancer cells and WEHI-164, Fibrosarcoma cells. Methanolic fractions of O. cuspidatum were prepared using solid phase extraction and the cells were treated with different concentrations for 12 and 24 hours. Cytotoxicity and cell viability were measured by MTT assay. ELISA was also employed to assess the histone-associated DNA fragments and the involvement of apoptotic mechanisms. 10 and 20% fractions had not significant cytotoxic effects (p>0.05) but other fractions exerted growth inhibition on both cancer cell lines (p
ISSN:2228-5881
2251-7308
DOI:10.5681/apb.2014.067