Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2

A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to different metal ions (Mn 2+ , Ca 2+ , Fe 2+ , Fe 3+ , Mg 2+ , Al 3+ , Ba 2+ , Ag + , Co 2+ , Na + , K + , Cu 2+ , Zn 2+ , Pb 2+ , Bi 3+ ) were studied by absorption and fluorescence titration. The results show that FPS has selective fluorescence sensing behavior for Zn 2+ ions and the limit of detection (LOD) was calculated to be 1.19 × 10 –8 mol/L. Moreover, FPS-Zn 2+ acts as a metal based highly selective and sensitive new chemosensor for Cu 2+ ions and the LOD was calculated to be 2.25 × 10 –7 mol/L. In accordance with the results and theoretical calculations, we suspected that the binding mechanisms of FPS to Zn 2+ and Cu 2+ were assigned to be the cooperative interaction of Zn 2+ (Cu 2+ )-N.