Alterations in power spectral density in motor- and pain-related networks on neuropathic pain after spinal cord injury

•Motor and pain-related intrinsic neural networks alter after spinal cord injury.•Alterations are inversely and simultaneously related to mobility and neuropathic pain.•Disabilities of mobility and neuropathic pain may be mutually influenced by supraspinal plasticity. The mechanisms by which mobility function and neuropathic pain are mutually influenced by supraspinal plasticity in motor- and pain-related brain networks following spinal cord injury (SCI) remains poorly understood. To determine cortical and subcortical resting-state network alterations using power spectral density (PSD) analysis and investigate the relationships between these intrinsic alterations and mobility function and neuropathic pain following SCI. A total of 41 patients with incomplete SCI and 33 healthy controls were included. The degree of mobility and balance function and severity of neuropathic pain and depressive mood were evaluated. The resting-state functional magnetic resonance imaging data of low-frequency fluctuations were analyzed based on PSD. Differences in PSD values between patients with SCI and controls were assessed using the two-sample t-test (false discovery rate-corrected P