Prevalence of ROS1 fusion in Chinese patients with non‐small cell lung cancer

Background The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non‐small cell lung cancer (NSCLC). Methods The presence of ROS1 fusion was assessed by quantitative real‐time PCR. Associations between ROS1 fusion and clin...

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Veröffentlicht in:	Thoracic cancer 2019-01, Vol.10 (1), p.47-53
Hauptverfasser:	Zhang, Qing, Wu, Chunyan, Ding, Wei, Zhang, Zhihong, Qiu, Xueshan, Mu, Dianbin, Zhang, Haiqing, Xi, Yanfeng, Zhou, Jianhua, Ma, Liheng, Fu, Shijun, Gao, Min, Wang, Bo, Deng, Juan, Lin, Dongmei, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - pathology Age Aged Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology China - epidemiology Clinicopathological features Female Gender Gene Rearrangement - genetics Genes Humans Lung cancer Male Metastasis Middle Aged Mutation Neoplasm Staging non‐small‐cell lung cancer Oncogene Proteins, Fusion - genetics Original Patients Precision medicine Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Response rates Retrospective Studies ROS1 fusion Sex Characteristics Smoking - adverse effects Smoking - genetics Tumors
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Zusammenfassung:	Background The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non‐small cell lung cancer (NSCLC). Methods The presence of ROS1 fusion was assessed by quantitative real‐time PCR. Associations between ROS1 fusion and clinical characteristics were analyzed. Results In total, 6066 patients with pathologically confirmed NSCLC and ROS1 fusion test results were enrolled. The average age was 60.89 ± 10.60 years and fusion was detected in 157 (2.59%) patients. Fusion frequency was significantly correlated with age, gender, smoking status (all P
ISSN:	1759-7706 1759-7714
DOI:	10.1111/1759-7714.12899