Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying e...

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Veröffentlicht in:	Nature communications 2019-10, Vol.10 (1), p.4857-11, Article 4857
Hauptverfasser:	Gallagher, C. S., Mäkinen, N., Harris, H. R., Rahmioglu, N., Uimari, O., Cook, J. P., Shigesi, N., Ferreira, T., Velez-Edwards, D. R., Edwards, T. L., Mortlock, S., Ruhioglu, Z., Day, F., Becker, C. M., Karhunen, V., Martikainen, H., Järvelin, M.-R., Cantor, R. M., Ridker, P. M., Terry, K. L., Buring, J. E., Gordon, S. D., Medland, S. E., Montgomery, G. W., Nyholt, D. R., Hinds, D. A., Tung, J. Y., Perry, J. R. B., Lind, P. A., Painter, J. N., Martin, N. G., Morris, A. P., Chasman, D. I., Missmer, S. A., Zondervan, K. T., Morton, C. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 631/208/205/2138 631/443/494 692/308/174 82/51 Adult Ataxia Telangiectasia Mutated Proteins - genetics Bleeding Chromosome 5 Economic analysis Endometriosis Endometriosis - epidemiology Endometriosis - genetics Epidemiology Female Fibroblast growth factor receptor 4 Fibroids Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Gene loci Genetic analysis Genome-Wide Association Study Genomes Health risks Humanities and Social Sciences Humans Hysterectomy Leiomyoma - complications Leiomyoma - epidemiology Leiomyoma - genetics Loci Mendelian Randomization Analysis Menopause Menorrhagia - etiology Menstruation Meta-analysis Middle Aged Morbidity multidisciplinary Muscles Neoplasms Origins Polymorphism, Single Nucleotide Proportional Hazards Models Receptor, Fibroblast Growth Factor, Type 4 - genetics Reproductive system Risk analysis Science Signal Transduction Smooth muscle Telomerase - genetics Tumors Uterine Neoplasms - complications Uterine Neoplasms - epidemiology Uterine Neoplasms - genetics Uterus White People - genetics
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Zusammenfassung:	Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant ( P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-12536-4