Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2- c ]Quinoline Derivatives as Potential Antileukemia Agents

Herein, we design and synthesize an array of benzofuro[3,2- ]quinolines starting from 3-(2-methoxyphenyl)quinolin-4(1 )ones via a sequential chlorination/demethylation, intramolecular cyclization pathway. This sequential transformation was efficient, conducted under metal-free and mild reaction cond...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2020-01, Vol.25 (1), p.203
Hauptverfasser: Lin, Ying, Xing, Dong, Wu, Wen-Biao, Xu, Gao-Ya, Yu, Li-Fang, Tang, Jie, Zhou, Yu-Bo, Li, Jia, Yang, Fan
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Sprache:eng
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Zusammenfassung:Herein, we design and synthesize an array of benzofuro[3,2- ]quinolines starting from 3-(2-methoxyphenyl)quinolin-4(1 )ones via a sequential chlorination/demethylation, intramolecular cyclization pathway. This sequential transformation was efficient, conducted under metal-free and mild reaction conditions, and yielded corresponding benzofuro[3,2- ]quinolines in high yields. In vitro biological evaluation indicated that such type of compounds showed excellent antileukemia activity and selectivity, and therefore may offer a promising hit compound for developing antileukemia compounds.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25010203