Transcriptome dysregulation in hyper-progressive disease samples with immune checkpoint blockade

According to the survival data of each patient and the definition of HPD,[2] four non-drug-responding samples were assigned to the HPD group [Supplementary Table 1, http://links.lww.com/CM9/B876]. Differential expression analysis showed that HPD samples had unique expression characteristics [Supplementary Figure 1, http://links.lww.com/CM9/B876]. The most significant gene of IR is Nod-like receptor (NLR) family caspase recruitment domain (CARD) containing 5 (NLRC5), a regulator of cancer immune escape. [...]our results showed that the tumor neoantigen delivery MHC-II pathway was upregulated, and the spliceosome factor SRSF2 was involved in changes in HPD-specific splicing.