Cryotherapy alone versus cryotherapy followed by intralesional vitamin D3 in treatment of anogenital warts: a randomized comparative clinical study

Background Anogenital warts (AGW) have an important impact on quality of life since they cause discomfort and shame. AGW cannot be effectively treated with a single technique. Objective To compare effectiveness and safety of intralesional vitamin D3 injection and cryotherapy in the treatment of AGW. Patients and methods A randomized comparative clinical study included patients with AGW attending to dermatology, Venerology and andrology clinics, Suez Canal University hospitals, Ismailia, Egypt. 36 patients were divided randomly into 2 groups, group A, included 18 patients who were treated with cryotherapy alone and group B that included 18 patients who were treated with cryotherapy then 0.25-1 ml of intralesional vitamin D3 injection in the same session. Results Complete response was obtained in 55.6% versus 94.4% of patients and clinical recurrence occurred in 27.9% versus 5.6% of patients in group A and B respectively (P