Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed...

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Veröffentlicht in:	TheScientificWorld 2013-01, Vol.2013 (2013), p.1-7
Hauptverfasser:	Barbosa Raposo, Nádia R., Silva, Adilson David da, Carmo, Antônio Márcio Resende do, Silva, Annelisa Farah da, Lima, Rebeca Mól, Lima, Larissa Lavorato
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Agaricales - chemistry Agaricales - enzymology Analogs Antioxidants - chemistry Aqueous solutions Biosynthesis Chemical properties Chemical synthesis Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzymes Fungal Proteins - chemistry Health aspects Methods Molecular Conformation Monophenol Monooxygenase - antagonists & inhibitors Phenols Phenols - chemistry Phosphotransferases Production processes Pyrones - chemistry Resveratrol Skin Stilbenes - chemistry Structure-Activity Relationship Studies Time Factors Tyrosinase Tyrosine
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Zusammenfassung:	This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P
ISSN:	2356-6140 1537-744X 1537-744X
DOI:	10.1155/2013/274643