A COMPARISON OF CLOMIPHENE CITRATE AND SEQUENTIAL CLOMIPHENE CITRATE PLUS HUMAN MENOPAUSAL GONADOTROPIN FOR USE IN CONJUNCTION WITH INTRAUTERINE INSEMINATION

There are currently ‎many different protocols in use for controlled ovarian hyperstimulation (COH), but the optimal method has ‎not yet been determined. To compare the outcome of COH using ‎clomiphene citrate (CC) versus CC plus human menopausal gonadotropin (hMG) in conjunction with intrauterine insemination (IUI), we studied 117 infertile couples‎. IUI with CC was used in 92 cycles ‎(group A) and IUI with CC plus hMG was used in 66 cycles (group B). ‎Data analysis demonstrated no significant difference between the two ‎groups with respect to patients’ age, duration and type of infertility, prior COH and endometrial thickness and pattern. Group A had a little ‎longer follicular phase length than group B. ‎Pregnancy rate for group A and B were 6.52% and 12.12%, respectively (P= 0.22). ‎Endometrial pattern and thickness had no impact on pregnancy rate. ‎There were no multiple gestation and obvious hyperstimulation syndrome. ‎For patients undergoing controlled ovarian hyperstimulation with IUI, ‎CC plus hMG protocol yields higher pregnancy rate than one using CC, although this ‎difference was not statistically significant because of limitation of number of ‎cycles.