Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China

Resistance to oseltamivir was observed in influenza A pandemic (H1N1) 2009 virus isolated from an untreated person in Hong Kong, China. Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occu...

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Veröffentlicht in:	Emerging infectious diseases 2009-12, Vol.15 (12), p.1970-1972
Hauptverfasser:	Chen, Honglin, Cheung, Chung Lam, Tai, Hung, Zhao, Pengxi, Chan, Jasper F W, Cheng, Vincent C C, Chan, Kwok Hung, Yuen, Kwok Yung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antiviral Agents - pharmacology China Dispatch Drug Resistance, Viral Female Health aspects Hong Kong Humans Influenza Influenza A Virus, H1N1 Subtype - drug effects Influenza viruses Mutation Neuraminidase - antagonists & inhibitors Neuraminidase - genetics Oseltamivir - pharmacology Oseltamivir resistance pandemic (H1N1) 2009 Public health quasi-species viruses
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Beschreibung
Zusammenfassung:	Resistance to oseltamivir was observed in influenza A pandemic (H1N1) 2009 virus isolated from an untreated person in Hong Kong, China. Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occurring NA 274Y mutation in this virus is necessary.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1512.091057