Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis

Several organic pollutants, including dioxins, furans, and coplanar polychlorinated biphenyls (PCBs), have become a growing concern due to their significant capacity for accumulation and migration across regions, as well as their extended half-lives and relatively high toxicity. Our study aimed to assess the impact of these pollutants on mortality, inflammatory states, and chronic diseases. Exposure was quantified in serum through high-resolution gas chromatography and isotope-dilution high-resolution mass spectrometry. Statistical analyses employed multivariate Cox regression, multivariate logistic regression, restricted cubic splines and subgroup analysis. The results indicated a significant increase in mortality (p