Iron in Micronutrient Powder Promotes an Unfavorable Gut Microbiota in Kenyan Infants

Iron supplementation may have adverse health effects in infants, probably through manipulation of the gut microbiome. Previous research in low-resource settings have focused primarily on anemic infants. This was a double blind, randomized, controlled trial of home fortification comparing multiple mi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nutrients 2017-07, Vol.9 (7), p.776
Hauptverfasser: Tang, Minghua, Frank, Daniel N, Hendricks, Audrey E, Ir, Diana, Esamai, Fabian, Liechty, Edward, Hambidge, K Michael, Krebs, Nancy F
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Iron supplementation may have adverse health effects in infants, probably through manipulation of the gut microbiome. Previous research in low-resource settings have focused primarily on anemic infants. This was a double blind, randomized, controlled trial of home fortification comparing multiple micronutrient powder (MNP) with and without iron. Six-month-old, non- or mildly anemic, predominantly-breastfed Kenyan infants in a rural malaria-endemic area were randomized to consume: (1) MNP containing 12.5 mg iron (MNP+Fe, = 13); (2) MNP containing no iron (MNP-Fe, = 13); or (3) Placebo (CONTROL, = 7), from 6-9 months of age. Fecal microbiota were profiled by high-throughput bacterial 16S rRNA gene sequencing. Markers of inflammation in serum and stool samples were also measured. At baseline, the most abundant phylum was Proteobacteria (37.6% of rRNA sequences). The proteobacterial genus was the most abundant genus across all phyla (30.1% of sequences). At the end of the intervention, the relative abundance of significantly decreased in MNP-Fe (-16.05 ± 6.9%, = 0.05) and CONTROL (-19.75 ± 4.5%, = 0.01), but not in the MNP+Fe group (-6.23 ± 9%, = 0.41). The second most abundant genus at baseline was (17.3%), the relative abundance of which significantly decreased in MNP+Fe (-6.38 ± 2.5%, = 0.02) and CONTROL (-8.05 ± 1.46%, = 0.01), but not in MNP-Fe (-4.27 ± 5%, = 0.4445). increased in MNP-Fe only (1.9 ± 0.5%, = 0.02). No significant differences were observed in inflammation markers, except for IL-8, which decreased in CONTROL. MNP fortification over three months in non- or mildly anemic Kenyan infants can potentially alter the gut microbiome. Consistent with previous research, addition of iron to the MNP may adversely affect the colonization of potential beneficial microbes and attenuate the decrease of potential pathogens.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9070776