Diagnostic accuracy of Cardiochek ® PA point-of-care testing (POCT) analyser with a 3-in-1 lipid panel for epidemiological surveys

Point-of-care testing (POCT) is commonly used in epidemiological surveys due to its various advantages, such as portability and immediate test results. The CardioChek PA analyser 3-in-1 lipid panel measures total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) cholesterol and low...

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Veröffentlicht in:Lipids in health and disease 2024-09, Vol.23 (1), p.297-9, Article 297
Hauptverfasser: Robert Lourdes, Tania Gayle, Chong, Zhuo Lin, Saminathan, Thamil Arasu, Abd Hamid, Hamizatul Akmal, Mat Rifin, Halizah, Wan, Kim Sui, Ab Majid, Nur Liana, Yoga Ratnam, Kishwen Kanna, Riyadzi, Mohd Ruhaizie, Ismail, Hasimah, Alias, Nazirah, Mohd Yusoff, Muhammad Fadhli
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Sprache:eng
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Zusammenfassung:Point-of-care testing (POCT) is commonly used in epidemiological surveys due to its various advantages, such as portability and immediate test results. The CardioChek PA analyser 3-in-1 lipid panel measures total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. This study tested the reliability and diagnostic accuracy of the CardioChek PA analyser using a 3-in-1 lipid panel. A cross-sectional study design with quota sampling was used. A total of 203 respondents aged 18 years and above from a research centre in the Ministry of Health, Malaysia, were recruited. Venous blood was sent to the laboratory and tested with Siemens Atellica CH, while a POCT analyser was used for capillary blood measurements. Intraclass coefficient correlation (ICC) analysis was employed to determine the agreement between capillary and venous blood parameters. The diagnostic performance of the evaluated tests was evaluated using STATA version 12. The agreement between capillary and laboratory venous blood was moderate (0.64-0.67) for TC and HDL, good (0.75) for LDL and excellent (0.91) for TG). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were as follows: TC, 57.1%, 94.3%, 92.3% and 64.8%; TG, 76.0%, 100%, 100%, and 96.6%; HDL, 96.2%, 83.2%, 47.2% and 99.3%; and LDL, 81.0%, 100%, 100% and 68.3%, respectively. The CardioChek PA analyser showed acceptable diagnostic accuracy for screening high-risk individuals more often in places where laboratories are inaccessible. It could also be used in clinical settings where patients would benefit from swift treatment decisions.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-024-02270-2