Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated...

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Veröffentlicht in:Nutrition & metabolism 2020-12, Vol.17 (1), p.105-105, Article 105
Hauptverfasser: Zheng, Peng-Fei, Yin, Rui-Xing, Guan, Yao-Zong, Wei, Bi-Liu, Liu, Chun-Xiao, Deng, Guo-Xiong
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Blood lipids
Cardiovascular disease
Cholesterol
Deoxyribonucleic acid
DNA
Enzymes
Ethnic groups
Females
Gel electrophoresis
Gender
Gene polymorphism
Genetic aspects
Genetic testing
Genotype
Genotype & phenotype
Glucose
Haplotypes
High density lipoprotein
Identification and classification
Laboratories
Lifestyles
Linkage analysis
Linkage disequilibrium
Lipids
Low density lipoprotein
Males
Medical research
Minority & ethnic groups
Notch protein
Notch receptor 4
Notch4 protein
Polymerase chain reaction
Polymorphism
Proteins
Restriction fragment length polymorphism
rs3134931
rs577272
Single nucleotide polymorphism
Single nucleotide polymorphisms
Solute carrier family 44 member 4
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Zusammenfassung:The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated subjects (Han, 1254; Maonan,1213) was obtained by using polymerase chain reaction and restriction fragment length polymorphism technique, combined with gel electrophoresis, and confirmed by direct sequencing. The genotype frequencies of SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs were different between Han and Maonan populations (P 
ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-020-00533-0