The application of special staining in neuropathological diagnosis

Special staining plays an important role in the clinical neuropathological diagnosis. Some special staining is used to distinguish the specific structure of neuron, such as Nissl staining for Nissl body. It can distinguish neuron from other cells, and can be used to judge the degree of neuron injury. Some special staining is used as the assistance of pathological diagnosis of some nervous system diseases. For example, in the primary demyelinating disease, Luxol Fast Blue staining is used to mark the demyelinating region; Bodian staining is used to label the relatively preserved axon; Holzer staining can show the abundant fine processes of reactively proliferative astrocytes, and so on. It will get twice the result with half the effort if pathologists use special staining as the assistance of clinical neuropathological diagnosis.