Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis

Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic review and meta-analysis discovered 204 relevant articles which...

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Veröffentlicht in:	Neurobiology of disease 2024-07, Vol.197, p.106520-106520, Article 106520
Hauptverfasser:	Frye, Richard E., Rincon, Nicole, McCarty, Patrick J., Brister, Danielle, Scheck, Adrienne C., Rossignol, Daniel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Spectrum disorder Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Biomarkers Biomarkers - metabolism DNA, Mitochondrial - genetics Environmental genetic interactions Humans Meta-analysis Mitochondria - metabolism Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Mitochondrial DNA Mitochondrial dysfunction Mitochondrial respiration Neurodevelopmental regression
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Zusammenfassung:	Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic review and meta-analysis discovered 204 relevant articles which evaluated biomarkers of mitochondrial dysfunction in ASD individuals. Significant elevations (all p
ISSN:	0969-9961 1095-953X
DOI:	10.1016/j.nbd.2024.106520