iTRAQ-based quantitative proteomic analysis of low molybdenum inducing thymus atrophy and participating in immune deficiency-related diseases

Molybdenum is a trace element with extremely uneven distribution in the environment. It constitutes the active sites of molybdenum enzymes that can catalyze redox reactions in almost all organisms. In this study, a mouse model with a low molybdenum diet was established to investigate the differentia...

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Veröffentlicht in:Ecotoxicology and environmental safety 2021-06, Vol.216, p.112200, Article 112200
Hauptverfasser: Zhang, Yan, Zhao, Jing, Zhou, Bian-hua, Tian, Er-jie, Tian, Wei-shun, Wang, Hong-wei
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Sprache:eng
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Zusammenfassung:Molybdenum is a trace element with extremely uneven distribution in the environment. It constitutes the active sites of molybdenum enzymes that can catalyze redox reactions in almost all organisms. In this study, a mouse model with a low molybdenum diet was established to investigate the differential protein expressions in the thymus and the mechanism of molybdenum regulating thymocyte development. Results showed that the thymus evidently atrophied, and the weight and organ index of the thymus substantially decreased under the condition of low molybdenum (P 
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2021.112200