Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy

The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with...

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Veröffentlicht in:	Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-14
Hauptverfasser:	Gerdle, B., Kosek, E., Mannerkorpi, K., Palstam, A., Bjersing, J., Löfgren, M., Bileviciute-Ljungar, I., Ghafouri, B., Christidis, N., Ernberg, M., Larsson, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunitet och inflammation Autoimmunity and Inflammation blood Blood & organ donations Clinical Study Cytokines Cytokines - blood Data processing Eotaxin Exercise Exercise - physiology Female Fibromyalgia Fibromyalgia - blood Fibromyalgia - immunology Fibromyalgia - therapy Humans IL-1β Immune system Immunology Inflammation Inflammation - blood Inflammation - immunology Inflammation - therapy Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 2 Interleukin 4 Interleukin 6 Interleukin 8 Interleukin-17 Interleukin-17 - blood Interleukin-1beta Interleukin-1beta - blood Interleukin-2 - blood Interleukin-4 - blood Interleukin-6 - blood Interleukin-8 - blood Intervention IP-10 protein Metabolism methods Middle Aged Nervous system Pain Physical fitness physiology Plasma levels Relaxation Relaxation Therapy Relaxation Therapy - methods Resistance Training Resistance Training - methods Studies Systematic review therapy Tumor necrosis factor Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Tumor necrosis factor-α Womens health γ-Interferon
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Zusammenfassung:	The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (n=49) or relaxation (n=43). Baseline IL-2, IL-6, TNF-α, IP-10, and eotaxin were higher in FM than in healthy controls (P
ISSN:	0962-9351 1466-1861 1466-1861
DOI:	10.1155/2018/3985154