Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study

Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induce...

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Veröffentlicht in:	Journal of basic & applied zoology 2022-06, Vol.83 (1), p.1-11, Article 28
Hauptverfasser:	Gadelmawla, Mohamed H. A., Alazzouni, Ahmed S., Farag, AbdelRazik H., Gabri, Mohamed S., Hassan, Basma N.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dimethylhydrazine 5-Fluorouracil Acids Apoptosis Biomedical and Life Sciences Cancer therapies Caspase-3 Cell Biology and Genetics Chemotherapy Colon cancer Colorectal cancer Colorectal carcinoma Cytotoxicity DNA methylation Ferulic acid Free radicals Humidity Laboratory animals Life Sciences Malignancy Morbidity P53 Side effects Tumors Zoology
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Zusammenfassung:	Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induced by 1,2-dimethylhydrazine (DMH). Results Regarding the colon tissues of male Wistar-albino rats ( Rattus norvegicus ), combined FA and 5FU showed the approximately normal structure of mucosa. The treated groups showed a remarkable reduction in Ki67, Ck20, and an elevation in caspase-3 and P53. There was significant upregulation of P53 in both 5FU and combined FA–5FU groups ( p
ISSN:	2090-990X 2090-990X
DOI:	10.1186/s41936-022-00293-8