A Novel Assisted Oocyte Activation Method Improves Fertilization in Patients With Recurrent Fertilization Failure

A Novel Assisted Oocyte Activation Method Improves Fertilization in Patients With Recurrent Fertilization Failure

Total fertilization failure (TFF) occurs in 1-3% of total intracytoplasmic sperm injection (ICSI) cycles and can reoccur in subsequent cycles. Despite the high success rate with the application of assisted oocyte activation (AOA), there is still a small number of couples who cannot obtain fertilized...

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Veröffentlicht in:Frontiers in cell and developmental biology 2021-07, Vol.9, p.672081-672081
Hauptverfasser: Wang, Meng, Zhu, Lixia, Liu, Chang, He, Hui, Wang, Cheng, Xing, Chenxi, Liu, Jinming, Yang, Liu, Xi, Qingsong, Jin, Lei
Format: Artikel
Sprache:eng
Schlagworte:
assisted oocyte activation
Cell and Developmental Biology
cycloheximide
fertilization
ionomycin
total fertilization failure
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Zusammenfassung:Total fertilization failure (TFF) occurs in 1-3% of total intracytoplasmic sperm injection (ICSI) cycles and can reoccur in subsequent cycles. Despite the high success rate with the application of assisted oocyte activation (AOA), there is still a small number of couples who cannot obtain fertilized eggs after conventional calcium (Ca ) ionophores-based ICSI-AOA. Six couples experiencing repeated TFF or low fertilization (
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.672081