Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance

From: 2011 International Conference on Molecular Neurodegeneration Shanghai, China 22-24 September 2011 Author details1-Division of Neuroscience, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USAEMPTY2-Department of Biochemistry and Molecular Biology, Medical College, Shandong University, Jinan, Shandong, 250012, ChinaEMPTY3-Nathan S. Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USAEMPTY4-NeuroInDx Inc., 1655 East 28th Street, Signal Hill, CA 90755, USAEMPTY5-Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USAEMPTY Supplemental Information: Methods We first determined whether PSA regulates Htt abundance in vivo using a human PSA (hPSA) transgenic mouse model, which was generated using bacterial artificial chromosome (BAC) mediated technology.