Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-01, Vol.26 (2), p.276
Hauptverfasser:	Sun, Jiayu, Li, Jie, Sun, Hongbao, Li, Chunling, Wu, Haoxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Biomedical materials bioorthogonal chemistry Chromatography concise synthesis Cycloaddition Reaction functionalized cyclobutene analogues Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Labeling Mass spectrometry NMR Nuclear magnetic resonance Potassium Proteins Scientific imaging tetrazine ligation
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Zusammenfassung:	Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26020276