Association of Phylogenomic Relatedness among Neisseria gonorrhoeae Strains with Antimicrobial Resistance, Austria, 2016-2020

We investigated genomic determinants of antimicrobial resistance in 1,318 Neisseria gonorrhoeae strains isolated in Austria during 2016–2020. Sequence type (ST) 9363 and ST11422 isolates had high rates of azithromycin resistance, and ST7363 isolates correlated with cephalosporin resistance. These re...

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Veröffentlicht in:	Emerging infectious diseases 2022-08, Vol.28 (8), p.1694-1698
Hauptverfasser:	Schaeffer, Justine, Lippert, Kathrin, Pleininger, Sonja, Stoger, Anna, Hasenberger, Petra, Stadlbauer, Silke, Heger, Florian, Eigentler, Angelika, Geusau, Alexandra, Indra, Alexander, Allerberger, Franz, Ruppitsch, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antimicrobial agents antimicrobial resistance Association of Phylogenomic Relatedness among Cephaloridine Cephalosporins core genome mutlilocus sequence typing Dispatch Dosage and administration Drug resistance Drug resistance in microorganisms extended-spectrum cephalosporins Genetic aspects Genomes Gonorrhea Health surveillance Identification and classification MLST Moxalactam Mutation Neisseria gonorrhoeae Patient outcomes Penicillin Public health Risk factors Strains with Antimicrobial Resistance, Austria, 2016–2020 Testing whole-genome sequencing
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Zusammenfassung:	We investigated genomic determinants of antimicrobial resistance in 1,318 Neisseria gonorrhoeae strains isolated in Austria during 2016–2020. Sequence type (ST) 9363 and ST11422 isolates had high rates of azithromycin resistance, and ST7363 isolates correlated with cephalosporin resistance. These results underline the benefit of genomic surveillance for antimicrobial resistance monitoring.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2808.220071