The impact of introduction of the 10-valent pneumococcal conjugate vaccine on pneumococcal carriage in Nigeria

The impact of introduction of the 10-valent pneumococcal conjugate vaccine on pneumococcal carriage in Nigeria

Pneumococcal conjugate vaccines (PCVs) protect against invasive pneumococcal disease (IPD) among vaccinees. However, at population level, this protection is driven by indirect effects. PCVs prevent nasopharyngeal acquisition of vaccine-serotype (VT) pneumococci, reducing onward transmission. Each di...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature communications 2023-05, Vol.14 (1), p.2666-9, Article 2666
Hauptverfasser: Adamu, Aishatu L., Ojal, J., Abubakar, Isa A., Odeyemi, Kofo A., Bello, Musa M., Okoromah, Christy A. N., Karia, Boniface, Karani, Angela, Akech, Donald, Inem, Victor, Scott, J. Anthony G., Adetifa, Ifedayo M. O.
Format: Artikel
Sprache:eng
Schlagworte:
631/326/590
692/699/255/1318
692/700/459/1748
692/700/478/174
Child
Children
Conjugates
Disease transmission
Humanities and Social Sciences
Humans
Impact analysis
multidisciplinary
Nigeria - epidemiology
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines
Reduction
Science
Science (multidisciplinary)
Streptococcus infections
Streptococcus pneumoniae
Vaccines
Vaccines, Conjugate
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Pneumococcal conjugate vaccines (PCVs) protect against invasive pneumococcal disease (IPD) among vaccinees. However, at population level, this protection is driven by indirect effects. PCVs prevent nasopharyngeal acquisition of vaccine-serotype (VT) pneumococci, reducing onward transmission. Each disease episode is preceded by infection from a carrier, so vaccine impacts on carriage provide a minimum estimate of disease reduction in settings lacking expensive IPD surveillance. We documented carriage prevalence and vaccine coverage in two settings in Nigeria annually (2016–2020) following PCV10 introduction in 2016. Among 4,684 rural participants, VT carriage prevalence fell from 21 to 12% as childhood (
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-38277-z